Alerts & Corrections

AHFS Drug Information/Essentials Update – July 2016

The July update to the AHFS Drug Information/Essentials database was published today. Highlights from this month’s update include:

New AHFS/Essentials Monographs

  • Daclatasvir (Daklinza®)
    • Daclatasvir dihydrochloride is used in conjunction with sofosbuvir (with or without ribavirin) for the treatment of chronic hepatitis C virus (HCV) genotype 1 or genotype 3 infection in adults who are treatment-naive (previously untreated) or previously treated, including those with cirrhosis (compensated or decompensated), liver transplant recipients, and those with human immunodeficiency virus (HIV) coinfection
  • Ombitasvir, paritaprevir, and ritonavir (Technivie®)
    • The fixed combination of ombitasvir, paritaprevir, and ritonavir (ombitasvir/paritaprevir/ritonavir) is used in conjunction with ribavirin for the treatment of chronic hepatitis C virus (HCV) genotype 4 infection in treatment-naive (previously untreated) or previously treated adults without cirrhosis

FDA MedWatch Alerts

  • Canagliflozin & Dapagliflozin
    • FDA has strengthened the existing warning about the risk of acute kidney injury for the type 2 diabetes medicines canagliflozin (Invokana, Invokamet) and dapagliflozin (Farxiga, Xigduo XR)
  • Aspirin
    • The FDA is warning consumers about the risk of serious bleeding when using nonprescription, also known as over-the-counter or OTC, aspirin-containing antacid products to treat heartburn, sour stomach, acid indigestion, or upset stomach
  • Sumatriptan
    • Sumatriptan iontophoretic transdermal system patch (Zecuity) manufacturer Teva Pharmaceuticals has decided to temporarily suspend sales, marketing, and distribution to investigate the cause of burns and scars associated with the sumatriptan iontophoretic transdermal system patch
  • Loperamide
    • FDA is warning that taking higher than recommended doses of the common over-the-counter (OTC) and prescription diarrhea medicine loperamide (Imodium), including through abuse or misuse of the product, can cause serious heart problems that can lead to death